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Study reveals missing link between high-fat diet, microbiota and heart disease

 

NutritionChat
(@nutritionchat)
Joined: 1 year ago
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Study reveals missing link between high-fat diet, microbiota and heart disease

High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide

A high-fat diet disrupts the biology of the gut’s inner lining and its microbial communities, and promotes the production of a metabolite that may contribute to heart disease.

... gut microbes and intestinal epithelial cells share a mutually beneficial relationship that promotes a healthy gut environment ... but a high-fat diet causes inflammation and damages the epithelial cells (impairing mitochondria); this causes more oxygen and nitrate, that stimulate the Enterobacteriaceae microbes (eg: E. coli) boosting TMA (trimethylamine), that is converted by the liver into TMAO (trimethylamine-N-oxide) increasing atherosclerosis and all-cause mortality.

... diet directly affects the host and promotes the growth of bad microbes.


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