Link Between Gut Microbiota and Chronic Inflammatory Diseases Like Arthritis

The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation

... a protein (phospholipase A2-IIA) naturally present in the gut acts on the microbiota and causes the formation of molecules that exacerbate the symptoms of chronic inflammatory diseases.

The protein has high affinity for bacterial membranes; it binds/splits them, releasing small molecules such as fatty acids (proinflammatory lipids). The action of phospholipase on gut microbiota also affects psoriasis and skin cancer.